Distribution of housekeeping genes, intensity of transcription, and the presence of active chromatin, as related to TAD profiles. (A) Distribution of housekeeping and tissue-specific genes, housekeeping, and developmental STARR-seq-identified enhancers around TAD boundaries from the S2 cells (red) and OSCs (blue). The proportion of a bin occupied by gene bodies (upper graphs) and the average number of enhancers in a bin (lower graphs) were calculated for all bins located at the same position relative to a TAD boundary. (B) Pie charts showing the distribution of differentially or uniformly transcribed bins in the four groups of bins defined by pairwise comparison of the cell lines (see the description in the text).
