Location of fusion within T2/Onc sequence indicates transposon mechanism of transcriptional alteration. (A) Map of a single copy of the T2/Onc transposon showing the locations of the various fusion products. The location of the fusion pair mapping to T2/Onc indicates how T2/Onc is modifying the transcript in order to generate the observed fusion event. (B) Transcriptional activation within the Capzb gene. (C) Transcriptional activation of the opposite strand of the Capzb gene. (D) Transcriptional activation on the opposite strand with apparent splicing in the Rere gene. (E) Premature truncation in Abca1. (F) Premature truncation and transcriptional activation happening at the same time in Abca1. Locations of LM-PCR junction fragments and fusion products are shown as described for Figure 1.
