RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

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Figure 2.
Figure 2.

Mapping to a modified mm9 genome. (A) IGV view of Eras genomic region from a tumor containing a transposon insertion. (B) Within the Eras transcript Exon 2, many unmapped read pairs were observed in the regions of fusions following mapping to the standard mm9 genome. (C) Remapping to the mm9 genome with added T2/Onc sequence reveals the presence of T2/Onc-genome fusion sequences. Many of the previously unmapped pairs now map to the T2/Onc sequence.

This Article

  1. Published in Advance November 9, 2015, doi: 10.1101/gr.188649.114 Genome Res. 26: 119-129

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