
Number of SNVs and indels removed after filtering with each additional VN sample. Black dashed line indicates the number of variants labeled as somatic when using only a database filter; red dashed line, the number of variants after correction with MN and the public databases; and the green dashed line, the golden set variants, those remaining after application of all correction methods. The shaded area indicates the number of variants remaining after VN filtering, ranging from all variants (upper bound) to highest-confidence somatic variants (lower bound).











