NMDA receptor signaling causes dramatic transcriptional changes. (A) Volcano plot showing up- and down-regulated genes upon NDMA treatment in TND10 neurons. The x-axis represents the fold change between control and NDMA in log2; the y-axis shows the adjusted P-value in −log10. (B) Bar plot showing fold induction of a few selected known synaptic activity and neuronal plasticity-related genes. The x-axis shows gain of expression fold change upon NMDA stimulation in neurons. (C,D) Browser tracks showing gain (C) and loss (D) of expression for key activity or neuronal-related genes. (E–H) Bar plots showing enrichment of biological processes and pathways in down-regulated (E,F) and up-regulated (G,H) genes upon NDMA stimulation. The bars reflect the number of genes in each category; the lines represent the multiple testing-corrected P-value, displayed as an alternate x-axis, of the corresponding GO term.
