Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers

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Figure 7.
Figure 7.

Model of transcriptional repression by NFκB-mediated cofactor redistribution. Following TNF treatment, cofactors redistribute to NFκB-activated enhancers, in particular, super-enhancers, near inflammatory genes. This redistribution occurs predominantly from the adipocyte basal super-enhancers that do not recruit RELA, thereby leading to specific repression of adipocyte genes associated with these super-enhancers.

This Article

  1. Published in Advance June 25, 2015, doi: 10.1101/gr.188300.114 Genome Res. 25: 1281-1294

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