Identifying evolutionarily conserved and accelerated human regulatory sequences. Schematic shows the framework for identifying DHSs that are conserved in primates but accelerated in the human lineage. DHSs appear as peaks of high coverage along the genome and are merged across cell types. An alignment (purple and gray boxes) of six primates is obtained for each DHS and the neutral sequence surrounding them. Black bars represent any sequence that differs from the human sequence, except in the case where all species differ from human, which are represented as blue bars in the human sequence. Dotted red lines indicate the location of the DHS.
