Figure 3.
SNP rs4266144 resides within a TEAD4 ChIP-seq binding site as assayed in HepG2 cells. The C > G variant is located in a largely invariant region of the TEAD4 canonical consensus binding motif. The binding site is located within a region that is enriched for H3K27ac and EP300 occupancy. Concordantly, ChromHMM segmentation analysis scores the locus as a putative weak enhancer (Ernst and Kellis 2012). Multispecies conservation analysis suggests that this motif resides within a region that is conserved between the great apes.
