Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

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Figure 6.
Figure 6.

Retrotransposons create CpG islands and sloping shores at the genomic scale. (A) Abundance of repeat CGIs and unique CGIs in the unmasked human genome. (B) Proportion of the four different types of repeat-associated CGIs. The schematic in C illustrates the relationship between a CGI and a repeat(s) in each type. (C) Contribution of individual repeat categories to each type of repeat CGI. (D) Comparison of repeat and unique CGIs according to the methylation status in sperm and somatic tissues. (E) A model for changing the DNA methylation landscape by retrotransposed CGIs. See text for details.

This Article

  1. Published in Advance May 20, 2015, doi: 10.1101/gr.185132.114 Genome Res. 25: 1135-1146

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