RT switching segments have a distinct sequence composition. (A) Characterization of a genomic region from Chromosome 6. Top panels display the gene density, GC content, and densities of interspersed repetitive sequences (LINEs and SINEs). Below are the RT profiles of the same genomic region in distinct cell types. Bars in each plot highlight segments of the Chromosome 6 replicating differentially in specific cell types. (B) Density contours were plotted for gene density, GC content, and densities of LINEs and SINEs. Correlations of distinct genomic features were calculated against RT from hESC and hepatocytes. The top and right side histograms depict the density distribution of each feature. (C) Box plots of gene density, GC content, densities of LINEs and SINEs, and GC content of constitutive (Early and Late) and switching 200-kb regions: (***) P < 0.001.
