
Germline mutation in genomic DNA is a fundamental resource for phenotypic variation, congenital disorders, and organism evolution. In this issue, a study demonstrates per generation de novo mutation rate in laboratory mice and the longterm phenotypic effects of mutation accumulation under a higher mutation-rate condition. The cover represents the transmission of DNA with de novo mutations from a parental mouse to offspring. (Cover illustration by Tom Wilson, t.wilson{at}aventdesign.com. [For details, see Uchimura et al., pp. 1125–1134.])