Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes

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Figure 1.
Figure 1.

Sumo is enriched at class III genes and RPGs. (A) Snapshots of the Sumo ChIP-seq experiment with FLAG-tagged Sumo (FLAG-SMT3) and untagged control cells (SMT3). (B,C) GO analysis of the ChIP-seq data set reveals highly significant overrepresentation of genes involved in translation, such as RPGs and class III genes. (D) Metagene analysis of Sumo distribution patterns at RPGs and class III genes. (E) Validation of ChIP-seq data by conventional ChIP-qPCR. Error bars indicate SEM of three independent experiments.

This Article

  1. Published in Advance March 23, 2015, doi: 10.1101/gr.185793.114 Genome Res. 25: 897-906

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