Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing

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Figure 4.
Figure 4.

Characterization of the hormone-responsive DHS time profiles. The hue-saturation-value color-space approach is used here in HSV scatter plots to depict both pulsed (A) and constant (B) treatments. Data are filtered for the effects of the mock treatment on DHS dynamics and reveal the kinetic behavior of the remaining DHS pool in an unbiased way and free of any threshold (see Supplemental Movie S2 for 3D versions). Sites displaying highly marked variations (i.e., one or two time points are almost 0) rise to the top of the graph as colorful dots, whereas sites with mild or no variations vanish to the bottom toward gray. Stronger sites, in terms of maximal readout, appear bright at the foreground, and weaker sites naturally disappear on the black background.

This Article

  1. Genome Res. 25: 845-857

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