Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

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Figure 5.
Figure 5.

Frequency and potential mechanisms of somatic mtDNA nuclear transfer in human cancer. (A) Estimated circular mtDNA copy numbers (in the cytoplasm) per cancer cell from 587 cancer tissues sequenced. The ratio of read depths between autosomes and mtDNA was used (see Methods). (B) Similar frequency of somatic nuclear mtDNA integrations compared to the frequency between autosomes (chromosomal translocation). (C) A model of somatic mtDNA transfer to the nuclear genomes.

This Article

  1. Published in Advance May 11, 2015, doi: 10.1101/gr.190470.115 Genome Res. 25: 814-824

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