Figure 4.
Nucleotide-resolution breakpoint sequences and the timing of somatic mtDNA nuclear integration. (A) Breakpoint sequences of nuclear-mtDNA fusions in PD13296a. Red rectangles highlight sequence microhomology and nontemplate nucleotides insertion. (B) Breakpoint sequences of nuclear-mtDNA fusions in PD6728b. Red rectangles highlight sequence microhomology. (C) Phylogenetic trees showing the timing of somatic mtDNA nuclear transfers in PD4252 and PD6728 samples. (MRCA) Most recent common ancestor cell.
