The human genome contains clusters of functionally related genes. (A) The 933 clusters of functionally related genes are present on all chromosomes examined. Chromosomes are arranged from 1 to X from left to right with functional clusters (orange), yellow bands indicate centromeres, and dark orange bands indicate regions of highly repetitive sequence; the banding pattern was obtained from UCSC Genome Browser hg18 (Rhead et al. 2010). (B,C) The extent of functional clusters compared to 1000 network node-label permutations of the PLN (see Methods), observed functional clusters are indicated by arrows with the respective P-value. The null distribution when paralogs were included is almost identical to that when paralogs were excluded, thus it is mostly hidden behind it in the plots.
