Figure 3.
Overview of de novo and inherited indel classes and their formation mechanisms. (A) Proportion of de novo and inherited indels by class. Inherited indels exhibit a 2.3-fold enrichment in indels located in homopolymer runs (HR) and tandem repeats (TR) when compared to de novo indels, suggesting lower selective pressures in these regions. (B) Outline of a plausible seven-step process that could account for the formation of a complex de novo indel by SD-MMEJ.
