Optimizing sparse sequencing of single cells for highly multiplex copy number profiling

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Figure 5.
Figure 5.

Single-cell copy number analysis reveals somatic mosaicism of chromosomal amplifications in Pt31. Genome-wide CNV plots at 20K bin resolution of representative single cells containing mosaic amplicons compared to bulk. (SIX6) SIX homeobox 6, (PREX1) phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1, (CCND1) cyclin D1, (TOP2A) topoisomerase (DNA) II alpha.

This Article

  1. Published in Advance April 9, 2015, doi: 10.1101/gr.188060.114 Genome Res. 25: 714-724

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