Regulation of PDGF- and NEDD9-pathway targets during in vitro infection. (A,B) Differential expression of PDGF- and NEDD9-target genes during infection of endothelial cells (A) and epithelial cells (B). Values represent log fold change expression relative to uninfected controls (RNA-seq expression values during infection divided by expression during uninfected mock infection). Yellow indicates increased expression during infection; blue indicates reduced expression during infection. (C) Differential expression of PDGF- and NEDD9-target genes during infection with invasion-defective C. albicans mutants. Values represent fold change differences in induction by mutant strain divided by induction by appropriate wild-type strain as determined by qRT-PCR.
