ceRNAts of lnceRNAs are functionally related. (A) Distribution of the mean linkage in an integrative functional network (Honti et al. 2014), for ceRNAts (median of mean linkage = 0.534, red) and miRNA-independent targets (median of mean linkage = 0.205, dark gray) of lnceRNAs. (B) Distribution of mean linkage weights for 1000 sets of randomly selected mESC-expressed genes. The red arrow indicates the mean linkage weight for ceRNAts of linc1316. The inset illustrates the connectivity of functional similarities (red edges) within miRNA-dependent target genes (red nodes). (C) Table illustrating Biological Processes Gene Ontology (GO) annotations that are significantly enriched within ceRNAts of linc1316 relative to a background of mESC-expressed genes. (*) P < 0.05.
