Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells

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Figure 4.
Figure 4.

MiRNA response elements shared between lnceRNAs and ceRNAts are conserved through mammalian evolution. (A) Histogram representing the substitution rate between mouse and human for a neutrally evolving sequence in the vicinity of lnceRNA MREs with the same length (ancestral repeats, ARs). Vertical arrow represents the substitution rate estimated for lnceRNA MREs (dMRE = 0.376). (B) Distribution of nucleotide substitution rate normalized by neutral local rate, between mouse and human, for predicted MREs (dMRE/dAR = 0.872, red) and non-MREs (dnonMRE/dAR = 0.977, gray) sequence within lnceRNAs. (C) Distribution of mouse-human substitution rate normalized by neutral local rate, measured at MREs shared between lnceRNAs and their ceRNAts (red, dMRE-shared/dAR = 0.831) and MREs for miRNAs not shared between lnceRNA and their targets (gray, dMRE-nonshared/dAR = 0.900). (***) P < 0.001.

This Article

  1. Published in Advance March 19, 2015, doi: 10.1101/gr.181974.114 Genome Res. 25: 655-666

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