Analysis of organelle genome rearrangements in Arabidopsis and humans. (A) Depiction of the types of rearrangement junctions observed by next-generation sequencing. Large arrows represent microhomologies and their orientation. Small triangles represent relative strand directions. (B) Proportion of rearrangements identified displaying a microhomology (≥5 bp) at their junction in each organelle. The mean of the four samples for brain and liver mitochondria is presented. (C) Proportion of short-range deletions/duplications and inversions (<1000 bp) displaying a gap of the indicated length. The y-axis represents the percentage of each type of rearrangement relative to its class size (gap length). A representative sample is shown for human brain (ERX385572) and liver (ERX385578) mitochondria. (D) Schematic representation of short-range inversions displaying a junction upstream, at the same base, or downstream on the opposite strand. The matrix strands are shown in blue, and the nascent strands in red, with the junction gap shown as a dotted line. (E) Proportion of short-range inversions (<50 bp) displaying a junction upstream, at the same base, or downstream on the opposite strand in each organelle genome. A representative sample is shown for human brain (ERX385572) and liver (ERX385578) mitochondria. (F) Proportion of total rearrangements corresponding to short-range inversions (<50 bp, U-turn-like rearrangements) in each organelle genome. The mean of the four samples for brain and liver mitochondria is presented. (Ara.) Arabidopsis, (mito.) mitochondrion, (del.) deletion, (dup.) duplication.
