Global variability in gene expression and alternative splicing is modulated by mitochondrial content

Mitochondrial contribution to variability in chromatin remodeling and transcription. Changes in mitochondrial content affect different molecular factors and biosynthetic processes involved in gene expression. (A) Mitochondrial contribution to variability in different epigenetic marks on histones associated with chromatin activation (yellow bars, “On” label) and chromatin repression (dark green bars, “Off” label). (B) Mitochondrial contribution to variability of factors responsible for transcription (green bars) and of transcriptional activities (measured as the amount of nascent RNA, Br-RNA, and total mRNA, poly[A], red bars).