
(A) Example of consistent domains. (B) Distribution of number of overlapping boundaries compared to a permutation control (binomial test 95% confidence interval error bars). Vertical dashed line denotes consistent boundary threshold. (C,D) Cumulative density of distances from consistent domain boundaries to the nearest (C) promoter and (D) distal CTCF motif. Distal CTCF motifs are defined as all CTCF motifs >5 kb from a promoter.











