Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell-type-specific expression

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Figure 1.
Figure 1.

(A) Strategy for incorporating Hi-C data using GBR. (B) Effect of GBR hyperparameters on topological domain agreement. The x-axis indicates the value of the graph weight hyperparameter λG. The y-axis indicates the average over 10 annotations (one for each input histone modification data set) of the fraction improvement in topological domain label agreement by adding GBR over Segway without GBR. (C) Same as B, but y-axis indicates improvement in replication timing standard deviation explained, and average is over 29 annotations. Annotations used four labels, 10-kb resolution.

This Article

  1. Published in Advance February 12, 2015, doi: 10.1101/gr.184341.114 Genome Res. 25: 544-557

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