Figure 5.
Long H3K9me3-marked heterochromatin domains have lower chromatin accessibility and partially methylated DNA. (A) NOMe-seq methylation levels and ChIP-seq enrichment Z-scores (excluding those within CpG islands) were averaged within each 1-Mb window in the genome. Each dot in each track shows the average value for the same 1-Mb window and which are ranked based on accessibility level in DKO1 (starred). (B) IGV browser view for a 33-Mb genomic window on Chr 2q. Multiple biological replicates are shown for H3K9me3 to illustrate the reproducibility in H3K9me3 domain shrinking.
