Figure 6.
Schema of DNA methylation at HBV integrants and flanking human genomic sequences. (A) DNA hypermethylation was seen in both the integrated HBV fragment and human genome (original human genome shows dense methylation). The HBV genome often showed significant methylation when integrated into highly methylated host sites. (B) DNA hypermethylation was rarely seen in the integrated HBV fragment and human genome (original human genome shows low methylation). The HBV genome remained largely unmethylated when integrated into unmethylated host sites.
