Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Competition for miRNA regulation. Cupid relies on evidence for competition for miRNA regulation, simultaneously identifying ceRNA and miRNA–target interactions. (A) A ceRNA network of oncogenes implicated in breast cancer regulation. Transfections of the 3′ UTRs of (B) CCND1, (C) ESR1, (D) HIF1A, and (E) PDGFRA in MCF7 up-regulated mRNA expression within the network, as measured by qPCR. Data are represented as mean ± SEM; (*) P < 0.05, (**) P < 0.01, (***) P < 0.001.

This Article

  1. Published in Advance November 5, 2014, doi: 10.1101/gr.178194.114 Genome Res. 25: 257-267

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research