Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes

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Figure 5.
Figure 5.

Analysis of Vα-Jα coding, Vα-Jα signal, and Jα-Jα hybrid junctions shows that Jα-Jα hybrids have processing characteristics similar to Vα-Jα coding junctions. (A) Frequency of nucleotide deletions flanking the RSS site of cleavage in coding Vα-Jα junctions (blue line), signal Vα-Jα junctions (black line), and hybrid Jα-Jα junctions (purple line). (B) Length of nontemplated bases in coding Vα-Jα junctions (blue line), signal Vα-Jα junctions (black line), and hybrid Jα-Jα junctions (purple line).

This Article

  1. Published in Advance November 3, 2014, doi: 10.1101/gr.179770.114 Genome Res. 25: 226-234

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