Maintenance of mitotic accessibility at promoters exceeds that of distal CRMs. (A) Box plots of read densities of peaks in interphase and mitosis color-coded by their classification as either promoter, distal CRMs (see main text and Supplemental Methods for detailed definitions), or “other” regions that do not correspond to these defined categories. Gray dotted horizontal lines mark the global background estimate of read density in all regions outside of hotspots. (B, top) Scatter plots (binned 2D density, produced similarly as in Fig. 3A) of mitosis versus interphase read density at the union of peaks across all samples, grouped by promoter versus distal CRMs peaks. (Bottom row) A zoomed-in view of the juxtaposition of the moving means for promoter and distal CRM peaks, with error bars denoting SEM from biological replicates (n = 3). Size of circles conveys the number of promoter or distal CRM peaks within each bin. (C) Box plot summaries of the mitosis-to-interphase ratio of read densities for hotspots and peaks. Horizontal dashed line marks location on y-axis where interphase read density is equal to mitosis read density.
