Figure 5.
HNF4A and CEBPA TF-dependent genes show divergent transcriptional output. (A) Evolutionary change for gene expression for TF-dependent versus TF-independent genes for the three TFs. Darker shading denotes the point-wise 95% confidence interval for TF-dependent genes, whereas lighter shading represents the interval for TF-independent genes. (B) Mean gene expression level across species for genes independent of the three TFs and TF-dependent genes for each of the TFs. P-values were calculated by comparing TF-dependent versus TF independent gene expression values using the Mann-Whitney U test.
