The chromatin environment shapes DNA replication origin organization and defines origin classes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Origin classes are linked to specific chromatin signatures. (A) Association of chromatin marks/factors within each class. Pearson correlation between pairs of chromatin marks/factors for all IS in each class. Class 1 IS (n = 28,443) are correlated with closed chromatin marks and anticorrelated with all other marks/factors. Class 2 IS (n = 14,873) are the only IS positively correlated with enhancer features (Enh.), whereas Class 3a and 3b IS (n = 10,547) are associated with Open 2 and Polycomb group (PcG) chromatin marks/factors. (B) ChIP-seq signals for 5hmC, H3K27me3, SUZ12, and H3K4me3 around ±7 kb from the center of Class 2 and Class 3a IS.

This Article

  1. Published in Advance November 11, 2015, doi: 10.1101/gr.192799.115 Genome Res. 25: 1873-1885

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research