Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryo

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Figure 7.
Figure 7.

Model for the role of Zld in defining chromatin accessibility at the MZT. (A) Zld determines chromatin accessibility at early embryonic enhancers, allowing other TFs access to their binding sites. (B) At a large subset of regions, Zld binds chromatin but is not required for accessibility. GAF facilitates open chromatin at regions that remain accessible in zldM- embryos, allowing transcription factors to bind to these loci. (C) Promoter regions are enriched among those regions that do not require Zld for accessibility.

This Article

  1. Published in Advance September 2, 2015, doi: 10.1101/gr.192682.115 Genome Res. 25: 1715-1726

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