Zld-mediated chromatin accessibility is correlated with early Zld-dependent gene expression. (A) Average ChIP-seq signal for Zld at cycle 14 for each class of FAIRE peaks. (B) FAIRE-enriched sites were associated with the nearest gene. For each associated gene, the expression change when maternal Zld was depleted was identified by RNA-seq. The percentage of genes that show a greater than twofold decrease in expression is plotted for each class of FAIRE peaks. Hypergeometric P-values are shown. (C,D) Correlation between Zld-mediated changes in gene expression and FAIRE signal for 83 genes expressed at nuclear cycles 10–11 (C) or 91 genes expressed at late nuclear cycle 14 (D). r = Spearman's correlation coefficient.
