DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts

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Figure 3.
Figure 3.

Global deregulation of the expression of protein-coding genes caused by DIS3 inactivation. (A) A volcano plot showing a large number of up-regulated and down-regulated transcripts. (B) A genome browser screenshot of TNFRSF9 mRNA transcripts, which are up-regulated in a cell line expressing the DIS3 PIN RNB double mutant. The RNA-seq signal was not supported by the PAR-CLIP signal. The uniquely mapped reads are shown for the minus strand. (C) Quantitative PCR validation of TNFRSF9 up-regulation in double mutants. Bars represent the standard deviation of three biological replicates.

This Article

  1. Published in Advance August 20, 2015, doi: 10.1101/gr.189597.115 Genome Res. 25: 1622-1633

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