Figure 5.
Chromosome 15 locus for abundance of genus Roseburia spp. (A) Overlapping genome-wide significant associations with the abundance of Roseburia spp. and liver and adipose eQTLs of the Irak4 gene in HMDP mice fed a HF/HS diet. The horizontal line indicates the threshold for genome-wide significance (P < 4 × 10−6). (B,C) Correlations of Irak4 adipose gene expression with the relative abundance of Roseburia spp. and HOMA-IR in the HMDP mice. (r) Biweight midcorrelation, (p) P value. See also Supplemental Tables 6 and 7.
