Figure 2.
Applications of single-cell sequencing in cancer research. This figure displays the myriad of applications that single-cell sequencing methods have in cancer research: (A) resolving intratumor heterogeneity; (B) investigating clonal evolution in primary tumors; (C) studying invasion in early stage cancers; (D) tracing metastatic dissemination; (E) genomic profiling of circulating tumor cells; (F) investigating mutation rates and mutator phenotypes; (G) understanding resistance evolution to therapy; (H) understanding cancer stem cells and cell hierarchies; and (I) studying cell plasticity and epithelial-to-mesenchymal transition.
