Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 7.
Figure 7.

HPL-2-bound genes that interact with the inner nuclear membrane are well expressed. (A) Venn diagram depicting the overlap of LEM-2-bound and HPL-2-bound genes in chromosome arms. (B) Box plots depicting median Z-scores of H3K9me2 (purple), H3K9me3 (blue), H3K27me3 (cyan), H3K4me3 (green), H3K36me3 (yellow), and Pol II (orange) ChIP-chip signal, as well as Z-scores of mRNA levels (red) of genes in arms bound by LEM-2 alone, both LEM-2 and HPL-2, or HPL-2 alone. Heatmaps of individual genes are shown in Supplemental Figure S8.

This Article

  1. Genome Res. 25: 76-88

Preprint Server