Figure 8.
Tandem mutations caused by Pol ζ. Black bars plot the frequencies of specific tandem mutations observed by Stone and coworkers in yeast deficient in nucleotide-excision repair machinery. Each mutation type is pooled with its reverse complement because there is no way to know on which DNA strand a mutation occurred. The two mutations GC → AA and GA → TT account for >60% of all tandem mutations observed by Stone and coworkers (Stone et al. 2012). As shown in gray, these are also the two most common types of mutations occurring at adjacent sites of the 1000 Genomes data in perfect LD.
