Figure 4.
Epigenetic activation of enhancers and insulators, in addition to promoters, in cancer cells. (A) Promoters (broadly, nucleosome-depleted, and H3K4me3 enriched) were defined in MCF7 cells. These exact genomic regions were subject to ChromHMM classification in HMEC cells, and the extent and type of epigenetic activation (nucleosome loss, acquisition of active epigenetic marks, and reduced DNA methylation) was determined at promoters (left panel, teal). Similarly, for insulators (broadly, nucleosome-depleted, and CTCF; center panel, purple) and enhancers (broadly, nucleosome-depleted, and H3K4me1 enriched; right panel, blue). (B) As in A, for PrEC and PC3 cells.
