The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Relationship between DNA methylation and gene expression. (A,B) Average methylation level of the promoters for genes ranked by expression level in E14-d0 and E14-d6. (C,D) Average methylation fidelity of the promoters for genes ranked by expression level in E14-d0 and E14-d6. The smoothed lines represent the average methylation level and fidelity surrounding TSSs calculated using 200-bp sliding windows.

This Article

  1. Genome Res. 24: 1296-1307

Preprint Server