HDAC inhibition confers H3K9/14 acetylation and deacetylation in the heart. C57BL/6 male mice were injected subcutaneously with TSA twice daily over a 4-wk period. (A) Image of hearts from control and TSA-injected mice. (B) Ideogram of differential H3K9/14ac regions for mouse (mm9) genome. (C) H3K9/14ac changes in mouse left ventricle calculated and shown as the total number of histone acetylation and deacetylation sites at intergenic regions, gene body, and promoter regions. (D) Distribution of H3K9/14 acetylation and deacetylation shown by genomic feature using Fisher’s exact test, represented as the log2 odds ratio. Error bars represent 95% confidence intervals. Feature annotation is described in the Methods.
