Figure 5.
HDAC inhibition by SAHA and TSA. H3K9/14ac at promoters of genes implicated in vascular endothelial function in response to TSA and SAHA stimulation are shown. (A) Increased STC1 gene expression was associated with promoter acetylation. (B) Reduced CCL2 gene expression was not associated with changes in histone acetylation. Reduced IL6 (C) and BMX (D) gene expression were associated with histone deacetylation. H3K9/14ac profiles shown are representative of three independent experiments. Kernel density estimation bandwidth: 200.
