Figure 4.
Characteristics of high- and low-occupancy binding regions. (A) Fraction of HOT, WARM, and COLD binding across the genomic regions described in Supplemental Figure S1. (B) Fraction of HOT, WARM, and COLD binding across the chromatin states described in Figure 1. (C) Mean phastCons score (10-bp window) across HOT, WARM, and COLD regions (center of region ±1 kb). (D) Mean phastCons score ± confidence interval (95%) for the central 100 bp of HOT, WARM, and COLD regions. Asterisks represent significant divergence from random ([**]P < 1 × 10−15; Wilcoxon rank sum test).
