Extreme HOT regions are CpG-dense promoters in C. elegans and humans

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

C. elegans HOT regions are functional promoters. (A) The indicated HOT regions (orange) were cloned directly upstream of a histone∷GFP fusion gene and examined for the expression of GFP using transgenic reporter assays. (B) Ten of ten assayed regions drove GFP expression. The expression in representative larvae stage 4 worms is shown. Coordinates of cloned regions and further information on expression patterns are shown in Supplemental Table S1.

This Article

  1. Published in Advance March 20, 2014, doi: 10.1101/gr.161992.113 Genome Res. 24: 1138-1146

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research