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Cover Inspired by M.C. Escher's artistic tessellations, the model organisms Drosophila melanogaster and Caenorhabditis elegans morph into human, reminding us of their common biology that has for decades informed human studies. In this issue of Genome Research, the National Human Genome Research Institute model organism ENCyclopedia Of DNA Elements (modENCODE) Project provides a comparative analysis of transcription, chromatin, and gene regulation across the three metazoan species, revealing important similarities and differences in their genome function. (Cover illustration by Darryl Leja, NHGRI, NIH. [For details, see Li et al., pp. 1086–1101; Lubelsky et al., pp. 1102–1114; Arthur et al., pp. 1115–1124; Chen et al., pp. 1209–1223; Slattery et al., pp. 1224–1235; and Wen et al., pp. 1236–1250.])