Inhibition of miR-29 up-regulates the secretion of multiple cytokines in MTB-infected DCs. Cytokine and chemokine concentrations in culture supernatants from transfected, infected cells were analyzed by multiplex bead immunoassay. (A) Relative cytokine/chemokine concentrations in miR-29 inhibitor-transfected cells compared with control-transfected samples ±SEM for duplicates of infection performed on four different donors. MiR-29 inhibition significantly increased the expression of 12 out of 22 cytokines. (**) P < 0.01. (B) Relative concentrations of the chemokine CXCL10 for mimic- and inhibitor-transfected cells, with respect to control-transfected samples, for duplicates of infection performed on four different donors.
