Differences in regulatory network architecture among classes of alternative splicing impact their regulatory divergence. (A) Skipped exons are more dynamically regulated throughout development. Violin plots show the distribution of switch scores (maximum percent inclusion minus minimum percent inclusion) for splicing events from each class of alternative splicing throughout development in D. melanogaster (Graveley et al. 2011). The median switch score (white dots) is highest for SE events. (B) Model of regulatory network differences among splicing classes. Skipped exons have a larger trans-mutational target size compared to other splicing classes and SE regulation diverges more rapidly through changes in trans-acting factors.
