A mobile insulator system to detect and disrupt cis-regulatory landscapes in vertebrates

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Figure 2.
Figure 2.

Expression disruption lines. (A–C) The lines ED185b (A), ED186 (B), and ED170 (C) show separated expression of GFP (green) and RFP (red). ED185b has expression of GFP in the neural crest (arrowhead) and RFP in the notochord (arrow). Also, both reporters show coexpression in the forebrain (asterisk). ED186 shows predominant expression of RFP in the eye (arrowhead) and central nervous system, while expression of GFP is restricted to very mild levels in the eye (arrowhead) and forebrain (asterisk). ED170 shows predominant expression of GFP in the notochord (arrow). (D) ED162 shows mostly coexpression of GFP and RFP in the central nervous system, having an exclusive domain of GFP expression in the otic vesicle (arrowhead).

This Article

  1. Published in Advance November 25, 2013, doi: 10.1101/gr.165654.113 Genome Res. 24: 487-495

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