A fine-scale recombination map of the human–chimpanzee ancestor reveals faster change in humans than in chimpanzees and a strong impact of GC-biased gene conversion

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

The human–chimpanzee ancestor map compared with the human and chimpanzee maps. (A) Mean absolute difference in recombination rate between the noninverted part of the ancestral, human, and chimpanzee maps (excl. chromosome 2) for nonoverlapping bins quadrupling from 10 kb to 2.56 Mb. Error bars indicate standard error of mean obtained by bootstrapping. (B) Spearman correlation between the noninverted part of the ancestral, human, and chimpanzee maps (excl. chromosome 2) for bins as in A. Confidence intervals for individual correlations and significance of difference between correlations were obtained by bootstrapping. The only comparisons not significant (P-values > 0.05) are ancestral–chimpanzee vs. ancestral–human for 40 kb and 2.56 Mb, and ancestral–human vs. human–chimpanzee for 640 kb and 2.56 Mb.

This Article

  1. Genome Res. 24: 467-474

Preprint Server